L.S.D., R.I.P.

Posted by Ampersand | January 19th, 2006

It saddens me that - apart from a few lucky areas with local producers - the drug LSD has ceased to exist. The one time the war on drugs actually succeeds in wiping a drug out, why must it be a drug I like? (They could have wiped out Meth instead. That would have been just fine with me).

Yes, some folks (me included) have very frightening or unpleasant experiences with LSD. But LSD, at best, creates an absolute conviction in the user that they’ve moved beyond the mind’s ever-present limitations of thought and perception, and that’s a stunning and worthwhile experience. The better LSD trips I had are probably the closest I’ll ever come to life-altering religious ecstasy.

(Admittedly, trying to talk about the experiences to folks who have never had them tends to make LSD users sound like our brains are made of slugs and we’ve had salt poured in our ears, but the near-impossibility of describing the experience is part of what makes it valuable.)

I don’t feel a strong desire to drop acid again. But I find it difficult to comprehend that my generation may have been the last generation (give or take) ever to have our minds blown into fractal patterns and endless connection-generating by LSD. That seems very unfair to the post-LSD generations - as if my generation had used up all the endless summer afternoons with perfect babbling brooks, or something, and no generation will ever get that feeling again.

* * *

Actually, what it reminds me of - and this analogy will probably get me in trouble - is September 11th, listening to the newscasters say that the World Trade Center was gone. Gone? Gone? How can it be gone?

I wasn’t reacting to the death toll - I was reacting to the idea that part of the skyline was gone. I used to spend my lunch breaks at the top of the WTC, looking over Manhattan while munching on a brown-bag sandwich. Surely the newscasters must be wrong. They must mean the buildings have been damaged. The towers are too big to ever be gone.

It wasn’t until later in the broadcasts - when they had footage of the buildings seemingly turning into powder and disintegrating, over and over - that I finally believed something that big and solid, could actually be gone.

Needless to say, the loss of life at the WTC makes that by far the more important loss. Nonetheless, in much the same way I found it hard to comprehend that the WTC could just be gone, I’m finding it hard to beleive that LSD is gone.

97 Responses to “L.S.D., R.I.P.”

  1. Nella Writes:

    Heh - i got put off taking acid by my dad saying that his one and only trip involved thinking the fridge was attacking him. I had enough weird phobias to contend with at the time without adding more. :-/


  2. arbitraryaardvark Writes:

    I think you are failing to account for the way markets operate. If there’s a demand, it’ll be filled. Have you tried outsourcing to India? Personally, now that I know I have mental health issues, I regret my (carefully controlled) experiments with the stuff, and of course getting busted when I was a teenager wasn’t fun, hard to explain to the bar examiners board.
    As far as I know it’s still around - ask your local dancesafe.org contact.
    If there’s a shortage, but still demand, price will rise to stimulate supply.
    The club kids I know tend to prefer obscure legal designer drugs.


  3. Lauren Writes:

    There is a small market for LSD that still exists, but it’s more likely for you to find ecstacy- and meth-laced drugs that promise an LSD high. The oddest thing I’ve ever heard travelling through town is synthetic mescaline which is purported to have ceased to exist sometime before the 1980s. Who knows what it was.

    I quit doing drugs a long time ago, but there was one long summer that I spent in a perpetual trip and I loved every waking (because I was always awake) minute. My punk rock friends would travel to Grateful Dead shows to buy up all the acid they could find, milling around uncomfortably with the deadheads, and promptly turn around and head back to town to sell it to us deviants. Is it inappropriate to share stories? Honestly, some of my favorite moments as a teenager involve LSD (don’t tell the children! *clutches pearls*).

    Anyhow, working with teenagers, I’ve overheard a few claiming that the availability of LSD is rare, but still floats around now and then. Like AA, says above, other designer drugs are the current trend. And then the timeless choice, pot.


  4. The Countess Writes:

    I’ve never had LSD. My mind makes it own fractal patterns on its own without any help from mind-altering drugs. ;)

    I heard opium is good. I’ve never had that either. I don’t know much about either drug. I prefer to not take any drugs at all. They’re illegal, for one thing, and I don’t like the idea of not being in control of my mind and body.


  5. Lauren Writes:

    Know what’s bizarre? I’m more bothered by this information than I ever thought I would be. Ha!

    Trish, if I had to do another drug again (besides drinking my lovely, lovely wine) I would choose LSD hands down. Smoking pot never did anything for me except make me grabby and prone to steal (no idea, don’t ask) where LSD was at least fun and stimulating. The high always lasted too long for me, but in a safe environment with other people it was a very enjoyable experience.


  6. RonF Writes:

    Acid was a lot of fun but it was damn dangerous, too. Back in the day many of us went on a few trips. Not all of us came all the way back.


  7. Samantha Writes:

    As a cheer-up exercise for the winter blahs around the new year I decided to make a list of the ten best days in my life. I surprised myself with how many of those days were spent tripping on either acid or shrooms, 6 out of 10.

    I agree with Amp that taking LSD is life-altering and share his mourning for its near impossibility to find anymore.


  8. John W Writes:

    I was a drug squad officer during late 60s and 70s. The dreadful effects of LSD do not seem to have materialised as claimed by the law makers of those times. I always thought that one of it’s drawbacks was the fact that one had no guarantee as to where the trip would lead one. Good and bad seemed to come with no pattern or cause. Better and more reliable stuff came about. The rebel pose that went with use of acid faded as people became more responsible about their drug use.


  9. hf Writes:

    I don’t like the idea of not being in control of my mind and body.

    I can’t resist pointing out that you don’t control your mind and body. To pick one well-proven and harmless example — well, mostly harmless — you can see your brain making decisions about what to show you, without asking your opinion or informing you at all.


  10. gengwall Writes:

    You know, I have never done any drugs (in the banned substances sense). Not even pot. I have no high moral claim to make here, they just never interested me.

    I do like Bill Cosby’s take on cocaine though:

    You ask someone why they take cocaine and they say something like: “well, it intensifies your personality”. And I say “Yes, but what if you’re an asshole!?”


  11. eataTREE Writes:

    Alas, poor LSD. Those stories your friend told you about your friend’s cousin’s friend who thinks he’s an orange notwithstanding, it was one of the few drugs where its reputation was actually scarier than its reality.

    I’m not so sure about the validity of LSD-inspired spiritual or religious experience, though. I think it simply lights up the “profundity” center of your brain, so you sit there, thinking “Oh, look. The cat. How profound! Oh look, the texture of the carpet. How profound!” and so on.

    I will say that it helped me obtain one very valid insight into the nature of reality: it exists entirely in your head. The external universe is unknown and unknowable. Your phenomenological experience, including your sensory impressions, is a show your brain is putting on for its own amusement.


  12. hf Writes:

    You ask someone why they take cocaine and they say something like: “well, it intensifies your personality”. And I say “Yes, but what if you’re an asshole!?”

    I caught an episode of That 70s Show where Mr. Counterculture gets a straight job with a tie. He hates the workload, and asks a co-worker how he gets the energy to do all this. I immediately thought, “Oh, so that’s how it got started!”


  13. lynne Writes:

    Ahhh. I spent a few years in my early 20’s where I occasionally would use LSD with my friends. I cant even describe how bonding the experience was. I never had a bad or frightening trip although sometimes I had pretty emotional ones filled with sadness. Mostly though, they were wonderful and they changed the way I look at the world. I hadnt thought about those times in years until I read a story recently about Albert Hoffman’s 100 birthday.

    It is funny because even though I havent had access to LSD in over 10 years, I just figured it was because as I aged, I was no longer hip enough to know people who could get it. Sometimes I would get cranky because it was illegal and it would be so nice to be able to go to the corner store and pick some up. It never occurred to me that this was because it was GONE. It is funny too because I think that if it were legal, I would still use it now and then.

    This line of yours: “That seems very unfair to the post-LSD generations - as if my generation had used up all the endless summer afternoons with perfect babbling brooks, or something, and no generation will ever get that feeling again” really sums up how I feel about this. wow.


  14. Mendy Writes:

    I’ve never been the type to try drugs (of the illegal sort), not even as a teenager rebelling. I did my fair share of drinking, but I got over even that fairly quickly. I’ve just never needed chemical stimulation to have a good time.

    And I’ve heard both amazing and horrifying LSD stories. I’ve even seen a few “bad trip” returns when I was an EMT. At this point, I’ve seen too much to ever do any of the drugs that my parents and friends did.

    I’ll get my near religious excstacy from a good glass of wine and wonderful music, and then there’s the high I get from really amazing sex. ;)


  15. beth Writes:

    you are free to take lsd or not take lsd if you wish. as someone with a psychiatric history, i dont feel it would be a good decision for me to take any hallucinogen.

    however. spare us the moral highgrounding on this issue. as someone who as at times used other drugs i know that the “fractal patterns” being referred to here are not the type that can be achieved in everyday life, without something to alter consciousness–that’s why they’re drugs, goddamnit. if anyone could get the same effect on their own, *no one* would use them.

    it doesn’t make you a better person not to have used drugs. it doesn’t make you a better person *to* have used drugs, either–basically, it makes your priorities and interests different. i wish people would realize and acknowledge this instead of lording it over the other side and thinking their choice to trip or not indicates their superiority.


  16. Twisty Writes:

    This kind of makes me feel the way I did when I found out they’d put a strip mall on the farm I grew up on. It’s really true that you can’t, as Wolfe says, go home again, but it sucks to be confronted with the actual evidence. Thirty years ago LSD was some of the best fun I’ve ever had, and even though I had no plans to ever do it again, it’s depressing to see yet another part of my idyllic youth gone forever. The older you get, the more little pieces of your old self crumble and disappear amongst the sands of eternity (insert sweeping orchestral flourish in E minor ).


  17. Radfem Writes:

    Acid was a lot of fun but it was damn dangerous, too. Back in the day many of us went on a few trips. Not all of us came all the way back.

    Yeah, my stepbrother was one of them. Still not back. LSD is one of the few drugs that actually can disqualify you from being in LE permanently b/c of its long-time and unpredictable effects. If it were to disappear, I’d be glad, but I know it’s not really gone. I’d be more happy if Meth were gone.

    I can live without seeing those particular “fractual patterns”, but you’re right in that it is about individual choice. Different strokes for different folks.

    Maybe it’s just me, but I think it’s better to just stay away from drugs, and work on the demand issue rather than the supply alone. Here, they busted a heroin dealer next to a school, but that doesn’t deal with the fact that students who want heroin or any other drug will get it elsewhere, b/c they want it or are curious about it. That might be a natural thing, but for many kids who are not White and/or middleclass, there’s no built in safety net in place if they become addicted to certain drugs like there often is with White kids. It’s not that there are necessarily more kids but in how they are treated. They have less resources to help them or their families than White middle-class or wealthier kids, and they are much, much more likely to be criminalized for the same thing. That’s the case for dealing as well, though I don’t like dealers, especially ones who take shots at my residence for trying to turn them in especially if they try to sell to kids or engage in violence. The ones who really make money and/or dealers in neighborhoods that are predominantly White or better off financially never get sent through the CJS. It’s most often the ones who sell to finance their own habits, or the smaller-level gangs.

    I’ve seen what they’ve done to family members who’ve faced or are facing addictions to meth and cocaine and to people in the community where I lived. Especially Meth, which is huge in these parts(more so than anywhere else in the country althugh the MidWest is catching up fast) and just one of the biggest and most painful scourges, though crack cocaine comes second.

    I despise the current war on drugs, in part having seen its affects up close which is that it just criminalizes generations of people in communities where most of the people are poor or nonwhite and there is a lot of good literature out there, such as the book, “White Lies”. They have less access to rehab programs even in Prop 36 hearings(Prop 36 emphasizes rehabilitation over incarceration of drug users) which is short of good inhouse rehab programs(which the prosecutors and police don’t mention when they cite 36 as a “failure”) anyway. Black and Hispanic drug users are more likely to be disqualified under prop 36 b/c they are more likely to be charged with resisting arrest(considered a violent crime even when it’s just verbal obstruction) than are Whites. In fact, in my county prop. 36 is the only courtroom where White defendants outnumber Black or Hispanic defendants.

    This is probably way off topic, and I’m trying not to be moralistic but it’s hard for me to see any topic on a drug and not think of what it’s been like here and elsewhere, especially having been the Meth capitol for so long. It’s a complex issue even when it seems it’s about a simple thing and it’s not one I’ve ever been able to separate into different issues.

    I’m trying not to say LSD–oooh bad, but it bothers me a bit as a person who is probably square when people are nostalgic about drug use. Maybe where you come from, there are positives, but from where I come from, the effects are often devastating and nearly all negative(a lot from the criminalization, but also from the reality of the nature of addictions).


  18. alsis39 Writes:

    I’d rather read about LSD trips than go on one. I feel the same way about bungee jumping.

    I bought a couple of fancy-schmancy kaleidoscopes several years back. I throw back a shot of bourbon and sit back with one when I get the urge for pretty colors in an altered state. Tame, I know… :o


  19. Ron O. Writes:

    My take is the ones who didn’t come back were probably pretty unstable to begin with. I don’t mean to minimize someone’s loss, but just because they are bad for some does not mean they are bad or should be banned for all. It is definitely not for everyone. Good clean acid contributed to some very special times during my teens and 20s. I have no desire to use regularly, but I thought I might again every few years. Guess that’s not going to happen.


  20. jcj Writes:

    Interesting post. I agree that a lot of it probably has to do with supply-and-demand. LSD doesn’t seem to have the same mythology and mystique surrounding it any more, the kind that grew up around it in the 60s (though I was born too late to get in on that)– the idea that everyone needed to have their mind blown, that this was the drug that was going to show us the true nature of God, ourselves and reality and revolutionize society. I don’t seem to meet many ‘mainstream’ young people nowadays who are really intrigued by the concept of an LSD spirituality or who want to “drop out” of the system. The most sought-after drugs seem to be ecstasy, meth and various designer drugs (among those I’ve talked to, anyway).

    Of course, this could also be regional– it still seems to be decently available in the San Francisco area (unsurprisingly), if what I’ve heard from friends is any indication.

    As re: what you do or don’t miss by not taking it: Drug evangelism seems to cut both ways (and hard)– on the one hand you’ve got the people saying “I don’t need drugs, life is all the high I’ll ever need, and all you people who turn to drugs for your kicks are pathetic” and on the other, the ones saying “it completely changes your life, it shows you God, you’ll never see the truth without drugs.” My own LSD experiences didn’t make me an evangelizer in either direction– no scare stories, but no big revelations either. I think it’s more that it’s possible to have certain insights under any condition, but the *feeling* of those insights under the influence of various drugs can be totally different. YMMV, since what insights I did get out of acid were somewhat mitigated by the fact that it made me very high-strung and jittery.

    Then again, I think allowance has to be made for neurological variation and what factor it might play in individual differences in responses to drugs, so that the extremes of opinion might represent what is honestly the case for some people. I have a somewhat ‘atypical’ neurology, so it might be possible that certain drugs just don’t have the same effect on me that they have on a more ‘normal’ brain wiring (it might explain why I don’t hallucinate, for one). Most of my really positive drug experiences have been with DXM (dextromethorphan, aka the stuff that’s in cough syrup), although I try to use that one sparingly. A lot of the good ones had to do with affirming that things I already suspected or believed were true (true for me, anyway), rather than discovering things that were new to me altogether.


  21. Mendy Writes:

    beth,

    My intention was not to “lord it over” anyone, but merely share my experiences and feelings. I don’t judge anyone for their particular choice of recreation, so long as they aren’t hurting anyone (eg drinking and driving).

    I’ve never been much of a thrill seeker, even in my youth.

    If I gave the impression that I was judging anyones behavior, I do apologize, because that certainly was not my intent.


  22. Tuomas Writes:

    My take is the ones who didn’t come back were probably pretty unstable to begin with.

    That’s what the ones who came back like to believe. It doesn’t make it true.

    Psychological defense mechanism, in other words (It will not happen to me!), and not really limited to drug use.

    FTR, I haven’t even smoken pot (sheltered rural youth) and I have no interest in starting any illegal drug now (I do drink occasionally, and am addicted to caffeine). Personally I’ve found out there are plenty of ways to have bonding experiences and great fun without them (or alcohol). Not here to judge, but anyway.


  23. Radfem Writes:

    My take is the ones who didn’t come back were probably pretty unstable to begin with.

    That may be true, but the problem is that many people do not know how “stable” they are, beforehand. That was certainly the case of my stepbrother.


  24. Charles Writes:

    I think of LSD as pretty much categorically different than all of the non-halucinogen drugs.

    I have the feeling, although I have no way of confirming it, that people who get badly messed up tripping start out by taking strong doses (the one person I know who was messed up by tripping took 3 hits on her first and only trip). I think that most people who start with a low dose trip under relatively stable conditions with a passable guide will, at worst, have an unpleasant experience, but not a crippling one, and I think that hte quality of that first experience probably provides some guidance of whether they should ever trip again. I have another friend who started with a half hit trip with a decent guide, found it interesting but felt it was potentially dangerous to her psyche, and never tripped again.

    I guess heavy and repeated use can also produce its own weirdness, but that seems like a different thing than the “I tripped once, and it messed me up badly,” experience.

    I wonder if people here who know people who were damaged by tripping know how much or how frequently that person was tripping. I’d be very interested to hear of a “I took half a hit (or a hit) once, and it messed me up badly” story, even second hand (or even a reliable third hand).

    The one person I know who was messed up badly by a single 3 hit trip had no warning signs that I could identify, even in retrospect (okay, maybe “finds the idea that the universe is all an illusion a horrifying and fearful idea” is a warning sign).


  25. La Lubu Writes:

    however. spare us the moral highgrounding on this issue. as someone who as at times used other drugs i know that the “fractal patterns” being referred to here are not the type that can be achieved in everyday life, without something to alter consciousness”“that’s why they’re drugs, goddamnit. if anyone could get the same effect on their own, *no one* would use them.

    Actually, that’s not true. You can achieve those “fractal patterns” through deep meditation or any variety of ecstatic religious experiences/practices, be they Christian, vodoun, pagan, Sufi, etc. Illness or physical exhaustion can get you there too. It’s just that drugs like LSD get you there faster, which is one of the reasons Timothy Leary advocated the use of LSD—modern folks (for the most part) don’t have the time or patience to reach that state of mind through the slower, old fashioned way.

    I wouldn’t worry too much, Amp. I’ll bet the CIA still keeps a stash! ;-)


  26. Ampersand Writes:

    I wouldn’t worry too much, Amp. I’ll bet the CIA still keeps a stash! ;-)

    Yes, but they’re bogarting it!


  27. Sheena Writes:

    ” just because they are bad for some does not mean they are bad or should be banned for all”

    Would you say the same about drinkg driving / DUI?


  28. Violet Socks Writes:

    Sigh. When I was growing up in hippie California, I couldn’t wait to try acid. It was on my list of things to do when I was an adult.

    It never happened, because I tried pot first and discovered that I am extremely sensitive to hallucinogens. I trip on pot. And they weren’t good trips, either. I decided I’d better not risk LSD. But it remains one of my regrets in life that I never experienced it.

    Opium, too — I would LOVE to smoke opium. But within 2 days of being on a morphine prescription for pain, I was planning to convert my entire backyard into a poppy farm so I could “always have this.” When I came to my senses I realized that my personality is probably just a tad too addictive for me to be messing with opiates.


  29. Charles Writes:

    Sheena,

    “ just because they are bad for some does not mean they are bad or should be banned for all”

    Would you say the same about drinkg driving / DUI?

    You weren’t asking me, but my answer would be “No.”

    Anyone who drives drunk is playing Russian roulette. Almost every drunk driver makes it home safely, but pretty much every drunk driver who finds themselves in a complicated interaction will mess it up badly, possibly killing someone in the process.

    Some small number of people who trip will mess up their minds badly. Some vanishingly small number will harm themselves or others. But most people who trip will not do either of those things, and people who won’t do either of those things on LSD will never do either of those things on LSD. The lottery is at the person specific level, not at the incident specific level.

    Every drunk driver is pretty much equal, but every tripper is not equal.

    Also, while there are presumably people who have accidentally killed others, and perhaps even murdered others, I suspect that bot hof those happen at rates not much higher than the general population. Drunk drivers do so at a much higher rate.

    LSD isn’t safe stuff, and it shouldn’t be available at the 7-11, but it is nowhere near as dangerous as driving drunk (or doing Meth at all).


  30. Charles Writes:

    [in a post awaiting moderation] I wrote the following mangled paragraph:

    Also, while there are presumably people who have accidentally killed others, and perhaps even murdered others, I suspect that bot hof those happen at rates not much higher than the general population. Drunk drivers do so at a much higher rate.

    That should have been “killed others while tripping …murdered others while tripping…” and “both of”.


  31. Lauren Writes:

    I have the feeling, although I have no way of confirming it, that people who get badly messed up tripping start out by taking strong doses (the one person I know who was messed up by tripping took 3 hits on her first and only trip).

    The first time I tripped I did it alone with a small stash a friend gave me — a strip of ten hits — thinking I would share it with others. Unfortunately I was young and dumb and thought a hit of acid was like a hit off a bong… and took all ten. It did mess me up for a few days, but I eventually came down still loving it.

    I might be crazy, but it probably isn’t due to the acid.


  32. kactus Writes:

    LSD is alright, but I always really loved shrooms. The way your face aches the next day cuz you just can’t stop laughing is a real hoot. But, sadly, due to various health-related issues, I’m scared of the big drugs now and just stick to weed, which at least I’m familiar with.


  33. Jake Squid Writes:

    I know of nobody who got messed up due to a single trip from a single hit or even multiple trips infrequently. Of the folks I know who sustained psychic damage, one decided to eradicate his personality by tripping continuously for months (he succeeded, unfortunately he didn’t think about replacing it), one took 17 hits at once & one, it became apparent to me during her horrid experience, had some serious issues beforehand that were unknown to her companions (plus it seemed to be some seriously strong stuff - and I didn’t remember that she took 3 hits - she was not well guided on that one). The first two I mentioned did what they did purposely. The third is an example of the dangers of LSD & why it should be approached more cautiously than most tripping novices (and veterans, for that matter) realize.


  34. Tapetum Writes:

    I’m sitting here reading all this nostalgia, and feeling a little…left out? Strange. I’ve never done drugs (even as an adult I rarely drink at all), mostly because I was viewed as too straight-laced in school for anyone to ever offer me any. At this point in my life I’m fairly grateful that I didn’t, since my subconscious at that age should have had a large “DANGER!” sign posted over it. Nonetheless, it might have been interesting to let go of the tight veneer of control for once.


  35. karpad Writes:

    I feel a bit left out honestly. hardest I’ve ever gone is alcohol (which due to a combination of genetics and weight, takes far, far too much effort to get to an altered state. it’s like having to eat a whole wet chihuahua to feel anything.)

    back in my school boy days, I was far too nerdy to bother (I had my D20s, god dammit). by the time I was cool enough to do anything like that, I was aware of certain personality limitations that tipped me off that anything hallucinogenic would not be my friend: that is to say, sober hallucinations that scare the crap outta me. If I were superstitious, I might think they were ghosts: roughly humanoid figures, but like an inky-black-to-slightly-hazy shadow. they’re rare, but always in the same region of my vision (roughly 20 degrees to the left or right off of straight ahead) which leads me to believe it might well be some visual phenomena based on some aspect of my eyes, but looking up from your computer screen to see a shadowman standing there for just that flicker will scare the fuck out of you.

    regardless of the actual origin of it, it has been more than enough to encourage me to avoid pretty much everything. Which is depressing, because I’m pretty sure I’d welcome happy hallucinations.

    so I have to halfass it by playing Katamari Damacy.

    anyway, I’m rambling now because I should be asleep, so I’m going to bed.


  36. hf Writes:

    (okay, maybe “finds the idea that the universe is all an illusion a horrifying and fearful idea” is a warning sign).

    I should think so! As La Lubu says, LSD can presumably work a lot more quickly than the sort of disciplines that Aleister Crowley taught. He recommended learning breathing exercises to calm fear before trying these slower techniques, as well as some knowledge of philosophy and a general scientific attitude.

    (plus it seemed to be some seriously strong stuff - and I didn’t remember that she took 3 hits - she was not well guided on that one).

    This leads to an interesting point. Dr. Leary said the effect of a drug depends on three factors: dosage, set (conditions in the mind of the user), and setting (objective). Prohibition, as Leary warned beforehand, has screwed our dosage calculations all to hell. It can’t have helped the “set” factor either. But I still tend to see the warnings as exaggerated.


  37. bladerunner Writes:

    What I want to know is why the hell are there numbers INSIDE a racquetball? I mean come on…why the hell would you need a number where no one can see it? That’s fucking hilarious! I can’t stop laughing about it…and on the inside of a traffic sign reflector too! Weird! LSD provides the bridge for relating the oddest smallest meaningless things to major philosophical concepts. It has changed the way I look at virtually everything.


  38. hf Writes:

    roughly humanoid figures, but like an inky-black-to-slightly-hazy shadow.

    Have you tried banishing them?* For that matter, have you tried talking to them? You need not assume their “objective reality or philosophic validity” in order to do this. Perhaps these figures (and/or your fear) represent part of your unconscious. Perhaps you can discover a goal in these appearances, and thus get them to change or stop.

    *I can think of other ways of banishing; when it comes to voices, someone I know does it by saying, “You don’t have to go home, but you can’t stay here.” (Your mind belongs to you, and you have the upper hand there — at least, if you hear the first part of this sentence and believe it.) I linked to that “Liber” because of what it says in section “I.”


  39. Elkins Writes:

    “If there’s something that you want to show me or to tell me, please do so now. If not, then I’d like for you to leave.”

    If there are other people around, of course, you can’t actually say that out loud without getting funny looks. But that’s okay. Saying it silently can work too.

    Of course, maybe they *will* show you or tell you something, which could be a scary concept. Then, it’s still better than having them just kind of hovering around and creeping the hell out of you, right?

    Another thing to consider: do you get enough good sleep, karpad? I only ask because the things you are seeing sound identical to something that troubled me a few years back, when I was having a very serious problem with insomnia (and its attendant sleep deprivation). When the sleep deprivation went away, the scary, shadowy ‘just-out-of-the-corner-of-my-eye’ figure thingumabobs went away with it.


  40. Nella Writes:

    “it doesn’t make you a better person not to have used drugs. it doesn’t make you a better person *to* have used drugs, either”“”

    Yes.


  41. feminist blogs Writes:

    - apart from a few lucky areas with local producers - the drug LSD has ceased to exist. The one time the war on drugs actually succeeds in wiping a drug out, why must it be a drug I like? (They could have wiped out Meth instead. That would have […]Continue reading at Alas, a blog … posted 4:32 am at Alas, a blog


  42. kactus Writes:

    Elkins, I’d like to know how you dealt with your insomnia problems. I have horrible intermittent insomnia, going on for about a year now, and it’s driving me nuts.


  43. Ledasmom Writes:

    Apparently most of you have had much more interesting lives, pharmaceutically speaking, than I. I do think my dentist is suspicious on account of my having had to ask him for replacement Valium due to having lost the prescription he’d given me after the last bout of dental work. It’s my opinion that, if you want someone to hang on to their Valium prescription, don’t give it to them while they’re still sedated on Valium.
    Now there’s a drug I’m glad isn’t legal: the first time I took it before dental work I didn’t notice anything for a bit - and then I stood up and tried to walk - and tripped on the carpet - and didn’t care. Just lay there face down on the carpet, giggling. They could have pulled all the teeth out of my jaw and played snooker with them and I wouldn’t have cared.


  44. kactus Writes:

    Hehe Ledasmom. When I last had major extractions they gave me laughing gas and I sat through the extraction and sobbed like a baby. No laughing for me, no sir. The dentist said that laughing gas is a misnomer–it’s as apt to make you cry as to laugh. And I get the valium thing too. What a lovely drug it is.


  45. Ron O. Writes:

    I knew that LSD was a powerful drug & I respected it from the beginning. But then I only do a small dose of any drug for the first time, even prescriptions. My friends & I only used when we had a safe time & location and someone stayed sober, aka “the trippersitter, sandwich maker”. I guess some damage can be done by people who are uninformed and incautious. But addiction to LSD is relatively rare. I’m far, far, more worried about folks who experiment with coke, meth, or x. Those are far more damaging drugs IMO.

    “it doesn’t make you a better person not to have used drugs. it doesn’t make you a better person *to* have used drugs, either”“”
    Agreed.


  46. Kelly Writes:

    It’s interesting that you say this drug is no longer available, as I know of no fewer than half a dozen separate sources where it is. Perhaps it’s an American thing, LSD being off the market, as it certainly is still around in Toronto.


  47. rabbit Writes:

    Its still reasonably available in the Chicago burbs, or at least was when I was in high school a few years ago. I have a hard time keeping my head together un-altered, and I’m really convinced that LSD has had a lasting effect on my sometimes inexplicably not-all-there mom…so I’ve never done it. But lots of my friends have, and they spend lots of effort convincing me its a life-altering experience…so don’t worry just yet that yours is the last generation to drop acid.


  48. karpad Writes:

    hf, such a course of action really isn’t nessicary. they’re entirely fleeting, so talking to them (or banishing with the power of denial) isn’t really feasible. This is a fraction-of-a-second kind of deal. it’s alot like those startling “holy shit what was that?” subliminal stuff in the Exorcist. you see it enough to know what it looks like, but not enough to know what it looks like, you know?

    but even if they were to become sustained, I think I’d rather ignore them. for all I know, they’d be dreamstalkers of Nyarlathotep, hoping to bring me into the fold as some kind of sorcerer summoner, and if I take your advice and I ask them a question, they get their fishhooks into my mind, and I end up summoning Hastur from Beyond the Gate. The only demon I’m interested in summoning is Palcor, Lord of Chocolates.

    and maybe Aliaria, Queen of Lust. but that’s a discussion for another day entirely.

    Elkins, your comment is rather apt. I get plenty of restful sleep (usually, although the last few days have been an exception), but it can take me several hours to fall asleep in the first place. It is possible I’ve had mild sleep deprivation for years now. not enough to feel lousy during waking hours, but just enough to do weird physiological things like that. assuming it’s the same thing, of course. it might be something completely different. though I’d still not want to drop acid, as I can’t imagine you’d get a very nice trip while sleep deprived.


  49. mangala Writes:

    Yeah, I’ve never done it myself, but it definitely does still exist in Toronto, as a few of my friends can attest.

    (Incidentally, Kelly - I just clicked on the link to your site, funny to run into someone else from Keswick here!)


  50. Ampersand Writes:

    Another reason to move to Canada….


  51. Elkins Writes:

    kactus, eventually I went to a doctor and was given a prescription for sleeping pills.

    Not a very holistic solution, I’m afraid, and I’m not ordinarily a very big fan of “better living through chemistry,” but sometimes there just don’t seem to be better choices available. It’s amazing how difficult it is to function once you’ve passed a certain threshold of chronic sleep deprivation, and the problem (in my experience, at any rate) has a way of snowballing on itself, which can make it really hard to kick it once it’s set in.


  52. mangala Writes:

    Well, wait until the current election plays out before making any permanent decisions! :P


  53. Mendy Writes:

    Elkins writes:

    Not a very holistic solution, I’m afraid, and I’m not ordinarily a very big fan of “better living through chemistry,” but sometimes there just don’t seem to be better choices available. It’s amazing how difficult it is to function once you’ve passed a certain threshold of chronic sleep deprivation, and the problem (in my experience, at any rate) has a way of snowballing on itself, which can make it really hard to kick it once it’s set in.

    Amen. Plus, with chronic sleep deprivation and insomnia there is a serious risk of doing harm to your brain. I suffer from insomnia, and have for most of my adult life. I tried everything, and then just settled on Ambien (which to me is the chemical equivalent to a snow shovel to the back of the head). I take one and sleep for about twelve hours.


  54. Ledasmom Writes:

    Kactus, laughing gas actually makes me laugh, embarrassingly loudly. The dentist said he had never seen anyone do that before, so I’m either very odd or highly suggestible.


  55. older Writes:

    I spent a lotta time in the acid zone, years ago, and I observed that almost everyone who had a really bad trip, and especially those who “didn’t come back,” were doing other drugs as well. I say “almost” only because I didn’t always know. More recently, I noticed that “acid” seems to contain other stuff these days. (In my day — she said in her creaky old voice — it was the pure blue.)

    I found that I was able to cure a long-standing infection by getting high and “talking” to the microbes. I’d be using it now, if I knew where to get an unadulterated supply.

    And Sheena, taking acid is not like driving drunk. Driving while on acid is the comparison you want. I don’t recommend it.


  56. kactus Writes:

    Two things on my mind: I wish like hell I could easily get a script for sleeping pills from my doc, but I also have chronic low blood pressure and I guess he’s afraid I’ll fall asleep and just not wake up. Which is a valid concern, but what it means is that I end up self-medicating when all my little tricks to fall asleep don’t work. I’ll buy ambien or soma or painkillers off the street, or over the counter stuff, just so that once or twice a week I get more than 2 or 3 hours of sleep. I mean, here it is 12:30 a.m. and I’m wide awake.

    Here in Milwaukee LSD is still available (at least according to my teenage daughter), but as I said earlier I don’t go for the heavy stuff anymore. What’s really becoming a problem now is heroin, especially among the young suburban kids. What a great drug *snark*.


  57. ErikaGillian Writes:

    Interesting, Ambien can cause hallucinations. But it also causes amnesia so you probably won’t remember the trip if it does.

    Radfem, what do you think about legalizing drugs? It wouldn’t stop the addiciton problems, but would the removal of criminal consequences help in your opinion?


  58. mark Writes:

    It’s not the same thing, but close … In Amsterdam, one can buy mushrooms in “smart shops”. About three years ago while in Amsterdam I took a low dose and visited the Stedelijk modern art museum (near the Van Gogh museum). Two thumbs way up.

    And travel should be cheap this time of year.


  59. Ledasmom Writes:

    That raises the question: If you look at modern art while on LSD, do you get Rembrandt?


  60. RowanCrisp Writes:

    I dropped acid pretty steadily for a few months (I was grieving, and depressed - all around not a fun girl to talk to at the time). I found that the trips (aside from the last one, which is one of the big reasons I quit) were enormously cleansing, as though I’d purged my emotional trauma.

    That last one, though - never take acid and go to the Hallowe’en Street Fair in WeHo.

    I imagine that LSD will have a comeback; humans by their very nature hunt down psychoactive agents. If not LSD, something else will rise to take it’s place.


  61. dorktastic Writes:

    Two quick points:
    I have also noticed that LSD is pretty widely available in at least the Greater Toronto Area of Canada. I have also noticed that by and large, drugs in Canada are often cheaper and of better quality than a lot of what you get in the US (at least, this has been the experience of many of the Americans I have talked to).
    I think LSD will eventually have a comeback. With the exception of pot, it seems that drug use also follows trends - cocaine has been pretty popular for the past few years, whereas not very many people seemed to be using it throughout 1990s.


  62. Aaron V. Writes:

    I seriously doubt that LSD is gone forever - look at the resurgence in home-distilled absinthe recently. It’s not as if the plant it came from went extinct.

    Someday, someone will wonder how those old people made those weird psychedelic band posters, and they’ll look up how to make LSD on whatever the Internet evolves into…

    I’ve had a very vanilla experience with substances - gallons of beer in high school and college, and pot whenever it gets brought out at a party.

    I volunteered for psychological experiments in college, and they did one test of my reflexes and motor skills while on speed, a depressant, or a placebo. I definitely noticed when I was on speed - it was one of the most unpleasant experiences of my life. I couldn’t sit down to relax myself for the tests.

    On the other hand, morphine was *very* pleasant when a doctor put me under before doing tests on me - I can see how people get addicted to opiates.


  63. Radfem Writes:

    Radfem, what do you think about legalizing drugs? It wouldn’t stop the addiciton problems, but would the removal of criminal consequences help in your opinion?

    This is an issue I think about a lot and ask myself a lot as well. I’m very conflicted, and I don’t see it as a blanket statement of legalization of all drugs either, which makes it harder to decide. All illegal drugs are clearly not the same. All impact individuals, families, societies differently. Legal drugs like tobacco and alcohol may not have their industries be affected by illegal trafficking but separately, they kill more people annually than every illegal drug combined. Do they kill people through disease and behavior(esp. alcohol’s role in homicide, rape and suicide) while legal than they did when illegal? How does the two balance out in terms of impact on life and quality of life issues? For users and families and society?

    It’s noted with alcohol and tobacco that there’s a period of illegality associated with ages of people using, i.e. teens, young adults, which may attract or deter use depending but a lot of people use both or being addicted to both at older ages as well.

    I don’t agree with prohibition of alcohol, which clearly was a mistake but I do understand why it happened. Many women drove this movement and their reasons weren’t crazy but had a lot of validity to them. They thought this would end crimes against women and families like DV and maybe rape too. It was an attempt to deal with serious issues, even if it was the wrong solution.

    This leads me to think that whether or not a drug is illegal doesn’t really matter as much, not that it doesn’t at all particularly with criminal issues and criminalization, but the issue is that of a supply being created to fill a demand. People want to do drugs or are addicted to them whether or not they are illegal or legal. That’s what you need to target, especially in youth. They use illegal drugs and they use legally produced substances in ways they weren’t intended for to get high, as well. And often times, the drug use is a substitute or an attempted fix of underlying problems, which remain unaddressed. It’s recreational in a sense, but really not. It fills a hole.

    And different drugs inflict different levels of damage. Makng them legal would change some of that, but leave others untouched. Meth, which is the worst illegal drug I can think of, is dangerous in the criminal sense, in that there’s some violence involved with trafficking of it among certain gangs(in my state, White supremacist and Latino gangs) as well as its production and crimes committed when using it. Meth labs do explode, which can costs lives especially if they are located in apartment buildings. Even decontaminating one is serious business, involving the evacuation of everyone within at least 400 feet of the lab. I’ve been through that process several times.

    Also, homes and apartments which have served as labs are a significant health risk to present or future inhabitants of those residences, many of whom have no clue of the places’ histories. A friend of mine moved from an apartment to a home rental which she found out later was once a meth lab. Now, she has to either move or pressure the landlord to decontaminate the home, an expensive and laborous process, or risk serious illness in herself and her kids.

    B/c of the prevalence of meth labs in my county(the highest in the nation), there’s been laws passed in attempts to stop or restrict the production by making the purchase of large amounts of ingrediants used in meth production illegal(i.e. pseudophedrine is sold behind the counter now in many places) But what that’s done is driven importation of meth and meth ingredients from Mexico. Why? Because even if you restrict a drug legally and impose criminal penalties, you still have high demand, b/c meth is an attractive drug and highly addictive. In its drive to demonize the use of marijuana, the feds have paid little attention to meth, which is spreading across the country like a weed.

    I’ve got a relative who’s a meth addict and no one knew for over a year b/c he’d gone to the doctor for treatment of a mental illness but didn’t say he was using meth. I suspected, but didn’t know for sure until he admitted it just recently.

    cocaine and crack have both had devastating impact on people and society, though their criminalization of users has added to the problem, not detracted. Crack gets more focus, mostly because of the demographics of its using and dealing population, though a lot of that is perception b/c Whites also use and deal in crack. Crack is also a drug associated with some sects of Crips and Bloods gangs, though at least locally, the CJS has not been successful in proving it’s production and sale is a gang enterprise, judging by the high number of gang enhancements associated with crack dealing cases which are tossed out by our very conservative judges.

    Periodically, there are stories of big busts but when you read more carefully, the drugs found per person involved is very small, meaning that they focus on the little guys and not the bigger fish that are out there who are scot free but might have the financial resources to fight their charges if they did get busted.

    Marijuana on the other hands, doesn’t bother me. I don’t like it, but I understand why people use it for medical reasons, or recreationally. I don’t see it as the national scourge.

    I definitely do not like the drug war and criminalization of drug use or the role of drug trafficking in U.S. foreign policy. Disproportionately, those who use drugs who are living in poor communities or are people of color are adversely affected by the enforcement of laws against drug use. If you are White and middle-class, you will be more likely to be steered towards rehabiliation programs than if you are Black, Latino and/or poor. The same, for drug dealers. Many Whites deal drugs, but they don’t fill the jail and prison cells.

    California is a state geared toward rehabiliation over punishment of drug addicts. Voters passed propositition 36 in response on this issue. The state and its agencies did not implement it aggressively in terms of ensuring adequate access by drug addicts to residential rehabilitation programs(which I noticed, sitting in during Prop 36 hearings), so now “studies” deem Prop 36 a failure, which isn’t really fair.

    I’ve got more on this, but this is a start. I’m still thinking…


  64. The Lynne Show (part 2) Writes:

    is for them to accept any other view or even accept facts that are in conflict with their view. I know I do this too but, of course, the areas where I do this are less obvious to me than when others do it. Here is one example: There was a pretty gooddiscussion about LSD on amptoons where I noticed many people making comments like “I haven’t done anything harder than alcohol.” I started to think about that. I mean, clearly the frame they are working with is that LSD is harder or worse than alcohol. But in what way? I suppose if


  65. scatters Writes:

    Its still around, you guys are to square to find it. If LSD was legal people wouldnt have to dip their sheets in AMT{I saw that on the DEA website}.
    If the government or lab scientist made LSD-25, acid would be safe. It is a worderful psyciatric tool that can cure depression, alcoholism, and many other metal diseases. It is also a spiritual tool that can bring you closer to god than a fiery babtist preachers sermon from a pull pit. Ancient cultures and cultures(some christian) that still exist today use it as a tool communicate with the holy Trinity(god as many people know him.) Leaglize it, Highten your spiritual experience, and say thanks and Happy Birthday to Mr. Albert Hoffman……..peace


  66. ya. Writes:

    lmao. WHERE in toronto??


  67. NowWeAreSix Writes:

    I never Came Back from my one and only trip. Im Bi-Polar and my friend thought it would be a great idea to give me 2 hits of LSD when i had never done anything else besides smoke weed. LSD is really easy to find for me. i could have 100 hits in my hand in just a few minutes. its based in sandiego. san francisco is going to get blown all over again.
    I Promise.


  68. jimmmm Writes:

    I’m here to tell you the perils of LSD. When I was eighteen, I took LSD and jumped out a window. It was on the ground floor, but after I jumped out the window, I went with my friends to the drive in to see “Prince of Darkness,” with Alice Cooper. It was the worst piece of crap I’d ever seen. I blame the acid.


  69. GIM Writes:

    I was one of the fortunates who experienced the cosmic, universal loving properties of LSD. For those of you who haven’t, I feel bad for you. I could have written what he wrote word for word. Stop believing all the negativities. Sure, some people have bad experiences on alcohol too. For us who have experienced the positive effects, I feel blessed and also I feel sorry for those who missed out. I, and the world, could use a few hits of Orange Sunshine right about now….trust me


  70. Mane Writes:

    LDS is great. Its easily available here, and the times on it (like now) are worth more than any of the amphetamine based experiences I have had. Amphetamines cause most of the problems in my area, and addiction is bad, mmmk. I hope the CHOICE stays for people to take whatever they feel nescassary, at the end of the day, we are alive and free do do what ever we want. I think as long as I dont affect anybody else, its fine.


  71. Tania Writes:

    LSD is the best drug experience I have ever had. I thought it was better than pot and better than shrooms (at least the kind of shrooms i had). I only wish that we had the freedom to take it as long as we don’t harm others. I wish the government did not have to be so paternal about the issue and let each person determine whether a drug like LSD is right for you or not… after reading so many of the postings here, I realize that more people than I expected are as responsible about their drug use as I try to be.

    Oh yeah, and about LSD being dead, it’s not! I tried it for the first time some weeks ago. I wish it was more readily available though! My friends had to drive two hours last time to score some.

    Anyone know where in America or Canada LSD is available?


  72. TheSeventhSign Writes:

    I also love LSD and wish it was more readily availible. I actually wrote a little article on another blog about all the acid being gone in Seattle. please go and check it out http://forums.thestranger.com/showthread.php?t=1509&referrerid=960. it might start you at the end of the thread but just scroll back a page to the beggining.
    I have decided to write a book about acid and if you have any “input” I would really appreciate it. You can email me my email address is theseventhsign@gmail.com
    to all the merry pranksters and other non-brainwashed brethren of mine. Please email me for my PO box #. I would really really love you and it would be a great begginning to my book. Thanks.


  73. Nick_P Writes:

    Hey everyone!
    I just wanted to post a comment to this subject after spending the las days (and the las 7 hrs) researching about the history, efects, and hole meaning behind LSD (movies, documentaries, articles, forums, etc).
    I have never done LSD, but lately and mostely after all this research, I have become really interested and facinated about this. About the experience that seems to have moved a hole generation (50s, 60s), all the ideas that have enriched the spiritual, artistic, phylosofical, intelectual, political aspects in the mind of so many poeple and even known people, and the way it was washed away due to the severe policy and (maybe exagerated) punishment for those who have any kind of contact or deal with these substance (see the William Leonard Pickard case).
    Its hard to beleve (as a 20 year old) that all this big part of human history had been so covered and hidden behind the perspective of drug use provided by our goverments and media, over the las decades.

    I would also like to add another fact that made me interested in this subject. While smoking weed, about one year ago when a was starting to get the taste of it, I had 2 occasions (the first one really really bad), when i felt something i never felt after again with marijuana (yeah maybe its weird but true), and that i still dont know what made the diference this times. The thing is that the second time, after knowing this feeling and just admitit in my mind, i had one of the most interesting hrs of my life, where i fell somehow, deep inside my thoughts and seeing a hole new percetion of reality, that made go and write and write about all these thoughts and ideas. So it became a little familiar with what i had heard about LSD, but of course with a tiny part of the intensity that you might get with this last. Thats why i seem to get a little of an idea of what LSD could mean. (I also talk about this to know if somebody ever experienced something like that only with weed or something).

    So anyway, Im not trying to say that everybody shoud try drugs or anywhing, on the contrary, i thing that the safest way (and if youre not curious) its to just stay away from drugs at all. But I also think that being a big issue and controversy in our society, people shoud get informed by diferent sources with diferent inclinations on the subject to be able to make their own judgement instead of just absorbing the fist thing you hear, and even more if you are planning to try some or if you think that you are closet to having access to them.

    Well maybe i could get some answers, and tell me what you think or if you agree or desagree with some of my ideas. Thanx, and bye!.


  74. Scott Writes:

    LSD is fantastic. I’m a college student, not from your generation. I just did LSD last night. I love LSD, it’s my favorite drug. It’s not impossble to find anymore, just harder. Yes, it is sad that the acid revolution is over, but for those who still seek the experience, it is available.

    Hopefully, when we overthrow capitalism, we will be free to do whatever drugs we choose.


  75. curt Writes:

    ====================
    = MAKING LSD =
    ====================
    LSD, being of the strangest drugs, is available to people on the black
    market, is not too hard to make in your average run-of-the-mill kitchen.
    LSD (LySergic acid Diethylamide) is a complex organic mixture that gives
    some people (most)
    ================================
    Making LSD: ITEMS NEEDED:
    1-About 200-250 grams of MORNIGLOR SEEDS or BAY HAWAIIAN OOD ROSE SEEDS.
    The Morning Glory Seeds can be obtained at most plant nurseries.
    2-200 cc. of petroleum ether
    3-Small piece of window screen or a strainer.
    4-A couple of large glasses.
    5-One cookie try (old on to never be used again).
    6-260 cc. of wood alcohol (call your local drug store).
    7-Capsule containers (jel)
    ================================
    Lets get started:
    1. Grind up about 170 grams of Morning Glory Seeds.
    2. In 145 cc of petroleum ether, soak the seeds for two or three days.
    3. With screen, filter the liquid thru it and save the seed mush and allow
    it to dry completely.
    4. Let the mush soak in 130 cc. of wood alcohol.
    5. Filter solution again only. Save the liquid in a large glass jar.
    6. Soak the seed mush again in 130 cc. of wood alcohol for two more days.
    7. Filter out the mush and keep the liquid. Now, get the liquid that was
    saved in step 5.
    8. Now, pour both liquids in a cookie tray and let it dry.
    9. When all the liquid has dried, a yellowish gummy looking substance will
    appear on the cookie sheet.
    10. Take the yellow gum and put these in to capsules.
    ================================
    You can get the capsules just by buying something like DEXITREM or some other
    pill. Even CONTACT comes in jel capsules. Just empty them out and
    put the yellow gum in the capsules. Allow the capsules to sit over night
    for best results.

    1 Trip:
    34 Grams of morning glory
    18 Grams of hawaiian wood
    ================================

    2nd way:

    Making LSD In The Laboratory

    ——————————————————————————–
    NOTICE: TO ALL CONCERNED Certain text files and messages contained on this site deal with activities and devices which would be in violation of various Federal, State, and local laws if actually carried out or constructed. The webmasters of this site do not advocate the breaking of any law. Our text files and message bases are for informational purposes only. We recommend that you contact your local law enforcement officials before undertaking any project based upon any information obtained from this or any other web site. We do not guarantee that any of the information contained on this system is correct, workable, or factual. We are not responsible for, nor do we assume any liability for, damages resulting from the use of any information on this site.
    ——————————————————————————–

    To make synthetic acid, you need a basic understanding of chemistry and access to a lab. Since I don’t quite understand all the chemical hocus- pocus, I’m going to cop out and quote you the patent for it. If you don’t understand chemistry, just skip this recipe and go on to the next one for acid, it’s much simpler.

    Preparation for Lysergic Acid Amides:

    United States Patent Office #2,736,728
    Patented February 28, 1956
    Richard P. Pioch, Indianapolis, Indiana, assignor, to Eli Lilly and Co., Indianapolis, Indiana, a corporation of Indiana.
    No drawing. Application December 6, 1954, Serial No. 473,443. 10 Claims.
    (Cl. 260-285.5)

    This invention relates to the preparation of lysergic acid amides and to a novel intermediate compound useful in the preparation of said amides. Although only a few natural and synthetic amides of lysergic acid are known, they possess a number of different and useful pharmacologic properties. Especially useful is ergonovine, the N-(1( )-1-hydroxyisopropyl) amide of d-lysergic acid, which is employed commercially as an oxytocic agent.

    Attempts to prepare lysergic acid amides amides by the usual methods of preparing amides, such as reacting an amine with lysergic acid chloride or with ester of lysergic acid, have been unsuccessful. United States Patents No. 2,090,429 and No. 2,090,430, describe processes of preparing lysergic acid amides and, although these processes are effective to accomplish the desired conversion of lysergic acid to one of its amides, they are not without certain disadvantages.

    By my invention I have provided a simple and convenient method of preparing lysergic acid amides, which comprises reacting lysergic acid with trifluoroacetic anhydride to produce a mixed anhydride of lysergic and trifluoroacetic acids, and when reacting the mixed anhydride with a nitrogenous base having at least one hydrogen linked to nitrogen. The resulting amide of lysergic acid is isolated from the reaction mixture by conventional means.

    The reaction of the lysergic and the trifluoroacetic anhydride is a low temperature reaction, that is, it must be carried out at a temperature below about 0 degrees C. The presently preferred temperature range is about -15 C. to about -20 C. This range is sufficiently high to permit the reaction to proceed at a desirably fast rate, but yet provides an adequate safeguard against a too rapid temperature and consequent excessive decomposition of the mixed anhydride.

    The reaction is carried out in a suitable dispersing agent, that is, one which is inert with respect to the reactants. The lysergic acid is relatively insoluble in dispersants suitable for carrying out the reaction, so it is suspended in the dispersant.

    Two gallons of trifluoroacetic anhydride are required per mol. of lysergic acid for the rapid and complete conversion of the lysergic acid into the mixed anhydride. It appears that one molecule of the anhydride associates with or favors an ionic adduct with one molecule of the lysergic which contains a basic nitrogen atom and that it is the adduct which reacts with a second molecule of trifluoroacetic anhydride to form the mixed anhydride along with one molecule of trifluoroacetic acid. The conversion of the lysergic acid to the mixed anhydride occurs within a relatively short time, but to insure a complete conversion the reaction is allowed to proceed for about one to three hours.

    The mixed anhydride of lysergic and trifluoroacetic acids is relatively unstable, especially at room temperature and above, and must be stored at a low temperature. This temperature instability of the mixed anhydride makes it desirable that it be converted into a lysergic acid amide without unnecessary delay. The mixed anhydride itself, since it contains a lysergic acid group, also can exist in the reaction mixture in large part as an ionic adduct with trifluoroacetic anhydride or trifluoroacetic acid. It is important for maximum yield of product that the lysergic acid employed in the reaction be dry. It is most convenient to dry the acid by heating it at about 105-110 degrees C. in a vacuum of about 1 mm. of mercury or less for a few hours, although any other customary means of drying can be used.

    The conversion of the mixed anhydride into an amide by reacting the anhydride with the nitrogenous base, such as an amino compound, can be carried out at room temperature or below. Most conveniently the reaction is carried out by adding the cold solution of the mixed anhydride to the amino compound or a solution thereof which is at about room temperature. Because of the acidic components present in the reaction mixture of the mixed anhydride, about five mols or equivalents of the amino compound are required per mole or equivalent of mixed anhydride for